Line clearance is the permission taken from the authorized QA person before starting actual production (Manufacturing, Filling and Packaging). 

The line clearance includes:

Manufacturing Area

Filling Area

Dispensing or packaging Area

Purpose and Importance

In line clearance the procedures have been established to prevent mix - up of containers, products, labels and mistakes in documents. MIx up and mistakes occurs when GMP are not followed.

Particular take should be taken:

When starting a new operation

At change of shift