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Tablet Coating: color variation Defects

During Tablet coating , color variation defect is observed sometimes.

 This defect is caused by improper mixing on the tablets, or by insufficient coating and also caused by uneven spray pattern on tablets.

 After coating the migration of soluble dyes or any additives during drying may give tablet a spotted and mottled apperation.

Due to this defect color variation is observed.

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Tablet coating: "Orange Peel Defect"

During tablet coating Orange peel defect is observed due to inadequate spraying or spreading of the coating solution.

Before the drying this coating solution causes bumpy or orange peel effect on the coating.

It is caused due to high spray rate and high pressure.

This defect can be prevented by thinning of the polymer solution and adding additional solvents.

What are "Tablet Coating - Defects"?

List of  some tablet coating defects which may affect the tablet formulation and bioavailability of drug are as follows.

(1) Picking and Sticking,

(2) Color variation,

(3) Orange peel effect,

(4) Twinning,

(5) Capping and lamination,

(6) Mottled color,

(7) Roughness,

(8) Hazing or Dull film

(9) Bridging,

(10) Erosion,

(11) Filling,

(12) Chipping,

(13) Blistering,

(14) Cracking,

(15)  Peeling and frosting.

Polymers applications in everyday life

Polymers have many applications in various fields as well as in everday life.

Let us check it out some uses of polymers.

 Polymers are used in clothing, oil recovery, food and flavours, agriculture, packaging, consumer items like clothing, toys, skin care

Polymers also used in automative parts, pipes, parts, additives etc.

Also used in electronics as well as in medicines such as in formulation of proteins, antibiotics, gel caps or in coating of tablets. 

Process Validation stages continued process verification one

About Process Validation, the third stage is continued process verification, Some more information about process validation in continued process verification are as follows:

The variation in the continued process verification can be detected by assessment of various documents.

By complaints of any defects.

By checking out of specification records or process parameters.

Checking deviation reports.

By observing variation in the process yield.

By checking batch records.

Checking records of incoming materials.

Polymers additives

Polymers additives is one of the applications in polymers to improve the mechanal property, durability or processability.

Fillers such as carbon black or silica gel are added to polymers to improve tensile strength, abrasion resistance and toughness.

Plasticizers are added to reduce the glass transition temperature.

Stabilizers contain antioxidants and UV protectants.

Lubricants are added to allow easier processing.

Other additives like colorants and flame retardants are also added in polymers. 

Process Validation parameters

Parameters of Process Validation for successful validation of any process are discussed here. Some of the key parameters in process validation are as follows, so let us check it out one by one.

The knowledge and the information about the product and the process is very necessary.

Understanding of the source of variation is required for successful process validation.

One must be aware about the impact of the variation on the process and ultimately on the products which is being manufactured.

Process Validation Stages process design two

In Process validation the first stage that is Process design stage have some points which are taken into account. Some of them which are taken into consideration are as follows:

Process control should address variability such as:

During the process design the control to reduce the input variation and the control to adjust for input variation are taken into account during manufacturing.

Controls may also consist of about the equipment monitoring at significant processing point and also control on material analysis.

Home Insurance

Home insurance is a kind of property insurance which covers private residence. This types of insurance gives protection to the home in which you are living and the things which you keep in it.

In home insurance policy damage caused by most of the disasters are covered but there are certain exemptions, Such as damage caused by floods, earthquake and other natural disasters. You need to take separate insurance policy for damage caused by earthquake or floods. 

Home insurance mainly covers building insurance and contents insurance.

Accident Insurance

Accident Insurance is a policy which insures against bodily injury or death caused by an accident. It also provides compensation for accidental injury. Accident Insurance does not cover death caused by acts of god or natural disaster. For that you need to take other types of insurance such as life insurace.

This type of policy is very good option for the people who lack health care coverage. Policy provides medical expense and proper treatment after an accident.

68 Applications of Nanotechnology - Overview of the applications of Nanotechnology

There are various applications of nanotechnology which we are going to discuss below. Nanotechnology provides various benefits in this world of technology. Smaller as well as cheaper, lighter, faster and clever things , which consume less raw materials and less energy can be prepared with the help of nanotechnology. It also offers various opportunities in creating various functions and new features. A team effort is required in creating any new feature with the help of nanotechnology

 

Full Form of PAN in Biology

PANFull form in Biology , its meaning and information is given below, so check it out some details on full form of the term PAN which is used in Biology.

The full form of PAN in biology is PAN Genome or Supra Genome. The term PAN can be considered as a  full complement of genes in a clade and it is  typically applied to the different species in bacteria.

PAN can have large variation in gene content among closely related strains.